2-(2-Aminoethyl)isothiourea dihydrobromide
Synonym(s):2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide;AET;S-(2-Aminoethyl)isothiouronium bromide hydrobromide;S-(2-Aminoethyl)thiouronium bromide hydrobromide
- CAS NO.：56-10-0
- Empirical Formula: C3H11Br2N3S
- Molecular Weight: 281.01
- MDL number: MFCD00037011
- EINECS: 200-257-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:13
What is 2-(2-Aminoethyl)isothiourea dihydrobromide?
Description
S-
Chemical properties
Crystals, hygroscopic.
The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide
2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).
The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide
NOS inhibitor
The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide
Has radioprotective activity against x-rays.
What are the applications of Application
S-(2-Aminoethyl)-ITU dihydrobromide is a selective inhibitor of NOS2 (iNOS)
Purification Methods
Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].
References
[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76.
Properties of 2-(2-Aminoethyl)isothiourea dihydrobromide
| Melting point: | 190-196 °C(lit.) |
| Density | 1.94 g/cm3 |
| storage temp. | Store below +30°C. |
| solubility | 50g/l |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | almost transparency |
| Merck | 14,178 |
| BRN | 3911163 |
| CAS DataBase Reference | 56-10-0(CAS DataBase Reference) |
| EPA Substance Registry System | Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide (56-10-0) |
Safety information for 2-(2-Aminoethyl)isothiourea dihydrobromide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(2-Aminoethyl)isothiourea dihydrobromide
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