(1R,2S)-2-fluorocyclopropanecarboxylic acid
- CAS NO.：167073-08-7
- Empirical Formula: C4H5FO2
- Molecular Weight: 104.08
- MDL number: MFCD19237658
- Update Date: 2025-07-16 09:56:27
What is (1R,2S)-2-fluorocyclopropanecarboxylic acid?
Synthesis
Dissolve benzyl alcohol and allyl bromide in the solvent, add sodium hydride, and perform a condensation reaction to obtain allyl benzyl ether. The obtained allyl benzyl ether, dichlorofluoromethane, and sodium hydroxide solution are raw materials for carbene reaction to obtain 2-chloro-2-fluorocyclopropylmethyl benzyl ether. Subsequently, the obtained 2-chloro-2-fluorocyclopropylmethylbenzyl ether is hydrogenated and reduced to obtain 2-chloro-2-fluorocyclopropanemethanol. Sodium hypochlorite is added as an oxidizing agent to perform an oxidation reaction to obtain 2-chloro-2-fluorocyclopropanecarboxylic acid. Finally, diethylamine is added to perform a hydrogenation reduction reaction to obtain (1R,2S)-2-fluorocyclopropanecarboxylic acid.
Properties of (1R,2S)-2-fluorocyclopropanecarboxylic acid
| Boiling point: | 202.3±33.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| pka | 4.00±0.11(Predicted) |
| InChI | InChI=1S/C4H5FO2/c5-3-1-2(3)4(6)7/h2-3H,1H2,(H,6,7)/t2-,3-/m0/s1 |
Safety information for (1R,2S)-2-fluorocyclopropanecarboxylic acid
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02 |
| GHS Hazard Statements |
H225:Flammable liquids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P243:Take precautionary measures against static discharge. P273:Avoid release to the environment. P403:Store in a well-ventilated place. |
Computed Descriptors for (1R,2S)-2-fluorocyclopropanecarboxylic acid
| InChIKey | HZQKMZGKYVDMCT-HRFVKAFMSA-N |
| SMILES | [C@H]1(C(O)=O)C[C@@H]1F |
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