(1R,2S)-2-fluorocyclopropanecarboxylic acid

CAS NO.：167073-08-7
Empirical Formula: C4H5FO2
Molecular Weight: 104.08
MDL number: MFCD19237658
Update Date: 2026-05-28 03:28:35

What is (1R,2S)-2-fluorocyclopropanecarboxylic acid?

Synthesis

Dissolve benzyl alcohol and allyl bromide in the solvent, add sodium hydride, and perform a condensation reaction to obtain allyl benzyl ether. The obtained allyl benzyl ether, dichlorofluoromethane, and sodium hydroxide solution are raw materials for carbene reaction to obtain 2-chloro-2-fluorocyclopropylmethyl benzyl ether. Subsequently, the obtained 2-chloro-2-fluorocyclopropylmethylbenzyl ether is hydrogenated and reduced to obtain 2-chloro-2-fluorocyclopropanemethanol. Sodium hypochlorite is added as an oxidizing agent to perform an oxidation reaction to obtain 2-chloro-2-fluorocyclopropanecarboxylic acid. Finally, diethylamine is added to perform a hydrogenation reduction reaction to obtain (1R,2S)-2-fluorocyclopropanecarboxylic acid.

Properties of (1R,2S)-2-fluorocyclopropanecarboxylic acid

Boiling point:	202.3±33.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
pka	4.00±0.11(Predicted)
InChI	InChI=1S/C4H5FO2/c5-3-1-2(3)4(6)7/h2-3H,1H2,(H,6,7)/t2-,3-/m0/s1

Safety information for (1R,2S)-2-fluorocyclopropanecarboxylic acid

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02
GHS Hazard Statements	H225:Flammable liquids
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P243:Take precautionary measures against static discharge. P273:Avoid release to the environment. P403:Store in a well-ventilated place.