(1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
- CAS NO.：180272-45-1
- Empirical Formula: C15H15N
- Molecular Weight: 209.29
- MDL number: MFCD11858641
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:08:34
What is (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline?
The Uses of (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.
Properties of (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
| Melting point: | 78-79℃ |
| Density | 1.065 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Beige |
Safety information for (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
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