(1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline

CAS NO.：180272-45-1
Empirical Formula: C15H15N
Molecular Weight: 209.29
MDL number: MFCD11858641
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline?

The Uses of (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.

Properties of (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline

Melting point:	78-79℃
Density	1.065
storage temp.	2-8°C
solubility	Chloroform (Slightly), Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Pale Beige

Safety information for (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.