1H-Imidazole-4-carboxylic acid

CAS NO.：1072-84-0
Empirical Formula: C4H4N2O2
Molecular Weight: 112.09
MDL number: MFCD00082203
EINECS: 214-017-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-07 16:53:29

What is 1H-Imidazole-4-carboxylic acid?

Chemical properties

Gray or tan powder

The Uses of 1H-Imidazole-4-carboxylic acid

4-Imidazolecarboxylic acid (ICA) was used in the synthesis of triphenymethyl-protected 4-imidazole carboxylic acid (trityl-ImCOOH) which is employed to functionalize poly(propylene imine) dendrimers.
It may be used in the following studies:

In the synthesis of lanthanide sulfate–carboxylates, [Ln(HIMC)(SO₄)(H₂O)] (Ln = Dy and Eu, HIMC = 4-imidazolecarboxylic acid) by in situ decarboxylation in the presence of Cu(II) ions.
As an internal standard to obtain calibration curve by plotting the peak area ratios of histamine (HA) and several metabolites isolated from C3H/HeNCrj mice hair relative to ICA.
In the synthesis of tetranuclear manganese carboxylate complexes possessing imidazole-based N/O chelating ligands.

What are the applications of Application

4-Imidazolecarboxylic acid is 4-Imidazolecarboxylic acid is used in the synthesis of imidazole functionalized poly(propylene imine) dendrimers.

General Description

4-Imidazolecarboxylic acid (1H-imidazole-4-carboxylic acid, H₂imc) is an imidazole derivative that contains an imidazole group and a carboxylate group. It has been widely utilized to generate different types of coordination polymers. The anion of 4-imidazolecarboxylic acid has been reported to stabilize binuclear hydroxo complexes of trivalent lanthanides in the pH range 7-10.

Properties of 1H-Imidazole-4-carboxylic acid

Melting point:	294-295 °C (lit.)
Boiling point:	495.0±18.0 °C(Predicted)
Density	1.524±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Aqueous Acid (sparingly)
form	Liquid
pka	2.69±0.10(Predicted)
color	Clear colorless
InChI	InChI=1S/C4H4N2O2/c7-4(8)3-1-5-2-6-3/h1-2H,(H,5,6)(H,7,8)
CAS DataBase Reference	1072-84-0(CAS DataBase Reference)

Safety information for 1H-Imidazole-4-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.