19(R)-HYDROXY PROSTAGLANDIN E1

Description

19(R)-hydroxy PGE₁ is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP₁ and EP₃ receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC₅₀ of 320 nM for contracting guinea pig ileum, which express EP₁ receptors, and an EC₅₀ of 80 nM for contracting chick ileum, which express EP₃ receptors.

The Uses of 19(R)-HYDROXY PROSTAGLANDIN E1

19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of 80 nM for contracting chick ileum, which express EP3 receptors.

What are the applications of Application

19(R)-hydroxy Prostaglandin E1 is a potent Prostaglandin E1 metabolite and agonist for the EP1 and EP3 receptor subtypes

Definition

ChEBI: 19R-Hydroxy-PGE1 is a prostanoid.