18alpha-Glycyrrhetinic acid
- CAS NO.：1449-05-4
- Empirical Formula: C30H46O4
- Molecular Weight: 470.68
- MDL number: MFCD00064897
- EINECS: 215-907-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 19:14:41
What is 18alpha-Glycyrrhetinic acid?
The Uses of 18alpha-Glycyrrhetinic acid
18α-Glycyrrhetinic acid may be used to synthesize:
- 3-keto-18α-glycyrrhetinic acid
- methyl esters of 18α-glycyrrhetinic acid
- methyl esters of 3-keto-18α-glycyrrhetinic acid
What are the applications of Application
18α-Glycyrrhetinic acid is the aglycone of glycyrrhizin
General Description
18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).
Properties of 18alpha-Glycyrrhetinic acid
| Melting point: | 331-333°C |
| Boiling point: | 492.11°C (rough estimate) |
| Density | 0.9967 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.71±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 1449-05-4(CAS DataBase Reference) |
Safety information for 18alpha-Glycyrrhetinic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 18alpha-Glycyrrhetinic acid
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