1,8-Naphthalaldehydic acid

Synonym(s):8-Formyl-1-naphthalenecarboxylic acid

Cream powder

1,8-Naphthalaldehydic acid may be used in the synthesis of fused bicyclic lactams, such as:

2,3,5,11b-tetrahydrobenz[de][1,3]oxazolo[3,2-a]isoquinolin-5-one
2,3,4,12b-tetrahydro-6H-benz[de][1,3]oxazino[3,2-a]isoquinolin-6-one
2,3,4,5,7,13b-hexahydrobenz[de][1,3]oxazepino[3,2-a]isoquinolin-7-one
1,2,3,11b-tetrahydro-5H-benz[de]imidazo[3,2-a]isoquinolin-5-one
1,2,3,4,6,12b-hexahydrobenzo[de]pyrimido[3,2-a]isoquinolin-7-one
1,2,3,4,5,13b-hexahydro-7H-benzo[de]1,3-diazepino[3,2-a]isoquinolin-7-one
7H-benzo[de]benzimidazo[3,2-a]isoquinolin-7-one
2,3,5,11b-tetrahydrobenzo[de]thiazolo[3,2-a]isoquinolin-5-one
(9S,9R)-methyl 5-oxo[2,3,5,11b]-tetrahydrobenz[de]oxazolo[3,2-a]isoquinoline-3-carboxylate
(3R,11bS)-3-phenyl-2,3,5,11b-tetrahydrobenz[de][1,3]oxazolo[2,3-a]isoquinolin-5-one

Journal of Medicinal Chemistry, 35, p. 823, 1992 DOI: 10.1021/jm00083a005

Melting point:	160-167 °C
Boiling point:	441.2±18.0 °C(Predicted)
Density	1.354±0.06 g/cm3(Predicted)
pka	2?+-.0.10(Predicted)
form	Powder
color	Cream
CAS DataBase Reference	5811-87-0
EPA Substance Registry System	8-Formyl-1-naphthalenecarboxylic acid (5811-87-0)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.