1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE

Synonym(s):2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride

CAS NO.：100991-92-2
Empirical Formula: C5H12ClNO3
Molecular Weight: 169.61
MDL number: MFCD03427380
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-20 16:56:23

1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Structural

What is 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE?

Description

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC₅₀ = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC₅₀s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.

The Uses of 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor.

What are the applications of Application

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is a glycogen phosphorylase inhibitor

General Description

1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid. It is found in Arachniodes standishii and Angylocalyx boutiqueanus.

Biochem/physiol Actions

Inhibitor of glycogen phosphorylase and α-glucosidases.

Properties of 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE

Melting point:	110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))
storage temp.	2-8°C
solubility	DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
form	A crystalline solid