1,4-dibromonaphthalene

CAS NO.：83-53-4
Empirical Formula: C10H6Br2
Molecular Weight: 285.96
MDL number: MFCD00041823
EINECS: 201-484-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-13 16:10:10

What is 1,4-dibromonaphthalene?

Chemical properties

light orange-beige fine crystalline powder

The Uses of 1,4-dibromonaphthalene

1,4-Dibromonaphthalene is used in the annelation of PAHs. Also used in the synthesis of novel, orally active dual NK1/NK2 antagonists.

What are the applications of Application

1,4-Dibromonaphthalene is an inhibitor of NK-1R and NK-2R

What are the applications of Application

1,4-Dibromonaphthalene is mainly used for pharmaceutical intermediates. synthesis of tribromo methoxynaphthalenes from 1,4-dibromonaphthalene. starting material 1,4-dibromonaphthalene was prepared starting from naphthalene or 1-bromonaphthalene.

5,8-Dibromo-1,4-naphthoquinone and 5,8-diiodo-1,4-naphthoquinone were prepared from 1,4-dibromonaphthalene and 1,4-diiodonaphthalene.

Preparation

An environment-friendly method was developed to synthesize 1,4-dibromonaphthalene (1,4-DBN) using 1,3-dialkylimidazolium and pyridinium ionic liquids as catalysts, over which the yields of 1,4-DBN were obtained as high as 100%.
An environment-friendly method for synthesis of 1,4-dibromo-naphthalene in aqueous solution of ionic liquids

Properties of 1,4-dibromonaphthalene

Melting point:	80-82 °C
Boiling point:	288.1°C (rough estimate)
Density	1.8199 (estimate)
vapor pressure	0-93.326Pa at 25℃
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, DMSO (Slightly), Methanol (Slightly)
form	Crystalline Powder or Crystals
color	White to light beige
Water Solubility	347.9ug/L(25 ºC)
CAS DataBase Reference	83-53-4(CAS DataBase Reference)
EPA Substance Registry System	Naphthalene, 1,4-dibromo- (83-53-4)

Safety information for 1,4-dibromonaphthalene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.