(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
Synonym(s):(1,3-Dioxolan-2-yl)-methyltriphenylphosphonium bromide;Triphenyl-1,3-dioxolan-2-ylmethylphosphonium bromide
- CAS NO.：52509-14-5
- Empirical Formula: C22H22BrO2P
- Molecular Weight: 429.29
- MDL number: MFCD00011966
- EINECS: 257-977-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:12:42
What is (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide?
Chemical properties
white to light brown granular powder
The Uses of (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.
The Uses of (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
Reactant for:
- Preparation of a ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione
- Microwave-assisted synthesis of KN-93 as inhibitor of calmodulin kinase II
- Preparation of fluorinated spirobenzofuran piperidines as s1 receptor ligands
- Synthesis and antitumor agents
- Regio-selective preparation of indole derivatives via rhodium-catalyzed domino hydroformylation/indolization
What are the applications of Application
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is a Wittig ylide reagent
Purification Methods
Wash the crystals with Et2O, dry them in a vacuum and recrystallise them from CH2Cl2/dry Et2O to give prisms m 172-174o, which is raised to 191.5-193o on drying at 56o/0.5mm. [Cresp et al. J Chem Soc, Perkin Trans 1 37 1974.]
Properties of (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
| Melting point: | 193-195 °C(lit.) |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Powder or Crystals |
| color | White to light brown |
| Water Solubility | Soluble in water (20°C). |
| Sensitive | Hygroscopic |
| CAS DataBase Reference | 52509-14-5(CAS DataBase Reference) |
Safety information for (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
| InChIKey | FRHRVQQUICVJDG-UHFFFAOYSA-M |
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