(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide

Chemical properties

white to light brown granular powder

The Uses of (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide

(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.

The Uses of (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide

Reactant for:

• Preparation of a ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione
• Microwave-assisted synthesis of KN-93 as inhibitor of calmodulin kinase II
• Preparation of fluorinated spirobenzofuran piperidines as s1 receptor ligands
• Synthesis and antitumor agents
• Regio-selective preparation of indole derivatives via rhodium-catalyzed domino hydroformylation/indolization

What are the applications of Application

(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is a Wittig ylide reagent

Purification Methods

Wash the crystals with Et2O, dry them in a vacuum and recrystallise them from CH2Cl2/dry Et2O to give prisms m 172-174o, which is raised to 191.5-193o on drying at 56o/0.5mm. [Cresp et al. J Chem Soc, Perkin Trans 1 37 1974.]