1,3-DIOXANE
Synonym(s):Formaldehyde trimethylene acetal
- CAS NO.：505-22-6
- Empirical Formula: C4H8O2
- Molecular Weight: 88.11
- MDL number: MFCD00006566
- EINECS: 208-005-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:02
What is 1,3-DIOXANE?
Chemical properties
colourless liquid
The Uses of 1,3-DIOXANE
1,3-Dioxane has been employed as solvent in the synthesis of 8- and 9-membered dioxazocines and dioxazonines.
Definition
ChEBI: 1,3-dioxane is a dioxane and a cyclic acetal.
Preparation
1,3-dioxane is prepared by the reaction of formaldehyde and 1,3-propanediol in the presence of Br?nsted or Lewis acid catalysts.
General Description
Clear colorless liquid.
Air & Water Reactions
Highly flammable. Can form dangerous peroxides when exposed to air. Water soluble.
Reactivity Profile
1,3-DIOXANE is sensitive to heat. 1,3-DIOXANE can react with oxidizers.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,3-DIOXANE emits acrid smoke and fumes.
Fire Hazard
1,3-DIOXANE is flammable.
Purification Methods
Dry the dioxane with sodium and fractionally distil it. [Beilstein 19/1 V 11.]
Properties of 1,3-DIOXANE
| Melting point: | -45 °C (lit.) |
| Boiling point: | 105-106 °C (lit.) |
| Density | 1.032 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 59 °F |
| storage temp. | Flammables area |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Water Solubility | Fully miscible in water. |
| BRN | 102532 |
| Stability: | Stable. Flammable. Incompatible with oxidizing agents. May form explosive peroxides in contact with the air - store under inert gas. |
| EPA Substance Registry System | 1,3-Dioxane (505-22-6) |
Safety information for 1,3-DIOXANE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 1,3-DIOXANE
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