1,3-DIOXANE
Synonym(s):Formaldehyde trimethylene acetal
- CAS NO.：505-22-6
- Empirical Formula: C4H8O2
- Molecular Weight: 88.11
- MDL number: MFCD00006566
- EINECS: 208-005-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:02
What is 1,3-DIOXANE?
Chemical properties
colourless liquid
The Uses of 1,3-DIOXANE
1,3-Dioxane has been employed as solvent in the synthesis of 8- and 9-membered dioxazocines and dioxazonines.
Definition
ChEBI: 1,3-dioxane is a dioxane and a cyclic acetal.
Preparation
1,3-dioxane is prepared by the reaction of formaldehyde and 1,3-propanediol in the presence of Br?nsted or Lewis acid catalysts.
General Description
Clear colorless liquid.
Air & Water Reactions
Highly flammable. Can form dangerous peroxides when exposed to air. Water soluble.
Reactivity Profile
1,3-DIOXANE is sensitive to heat. 1,3-DIOXANE can react with oxidizers.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,3-DIOXANE emits acrid smoke and fumes.
Fire Hazard
1,3-DIOXANE is flammable.
Purification Methods
Dry the dioxane with sodium and fractionally distil it. [Beilstein 19/1 V 11.]
Properties of 1,3-DIOXANE
| Melting point: | -45 °C (lit.) |
| Boiling point: | 105-106 °C (lit.) |
| Density | 1.032 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 59 °F |
| storage temp. | Flammables area |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Water Solubility | Fully miscible in water. |
| BRN | 102532 |
| Stability: | Stable. Flammable. Incompatible with oxidizing agents. May form explosive peroxides in contact with the air - store under inert gas. |
| EPA Substance Registry System | 1,3-Dioxane (505-22-6) |
Safety information for 1,3-DIOXANE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 1,3-DIOXANE
New Products
Methyl N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-N-nitroso-L-valinate Levofloxacin - Impurity B/ Levofloxacin Related Compound A Ivabradine R isomer Escitalopram - Impurity K Escitalopram Cyno dilol Impurity Paroxetine EP impurity I/Paroxetine Anhydrous EP Impurity I 2-Amino-5-Bromo-6-Chloropyridine 3-Amino-5-bromopicolinic acid 1-(7,8-Dinitro-4,5-dihydro-1H-1,5-methanobenzo[d]azepin-3(2H)-yl)-2,2,2-trifluoroethanone 2-Amino-3-Bromo-5-Cyanopyridine 2-Amino-3-Chloropyridine 2,5-Dibromo-3-MethylpyridineRelated products of tetrahydrofuran
![2,4,8,10-TETRAOXASPIRO[5.5]UNDECANE](https://img.chemicalbook.in/CAS/GIF/126-54-5.gif)
You may like
-
1,3-Dioxane 505-22-6 99%View Details
505-22-6 -
1,3-Dioxane CAS 505-22-6View Details
505-22-6 -
1,3-Dioxane CAS 505-22-6View Details
505-22-6 -
17471-10-2 Diphenhydramine EP impurity-A /Diphenhydramine Related Compound A NLT 95%View Details
17471-10-2 -
Dorzolamide Related Compound B/Dorzolamide EP Impurity B NLT 95%View Details
120279-90-5 -
76824-16-3 Famotidine - Impurity D NLT 95%View Details
76824-16-3 -
118-23-0 NLT 95%View Details
118-23-0 -
573704-41-3 NLT 95%View Details
573704-41-3
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.