1,3-Diaminopropane

Synonym(s):TMEDA;DAP;1,3-Diaminopropane;1,3-Propanediamine;Trimethylenediamine

CAS NO.：109-76-2
Empirical Formula: C3H10N2
Molecular Weight: 74.12
MDL number: MFCD00008228
EINECS: 203-702-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:25:22

What is 1,3-Diaminopropane?

Chemical properties

colourless liquid

The Uses of 1,3-Diaminopropane

1,3-Diaminopropane is commonly used in the preparation of cholinesterase inhibitors and thrombosis inhibitors. It is also used as a polymer cross linkage agent, polyurethane extender and spray coatings. It is involved in the preparation of agrochemicals and pharmaceutical intermediates. Further, it acts as a building block in the synthesis of heterocyclic compounds, which finds application in textile finishing. In addition to this, it is used as a ligand and form coordination complexes.

What are the applications of Application

1,3-Diaminopropane is a common synthesis reagent

Definition

ChEBI: An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.

Production Methods

1,3-Diaminopropane is produced in a twostage continuous process, under a pressure of 10 – 20 MPa. In a first reactor, acrylonitrile reacts with excess ammonia at 70 – 100 ℃ to give 2-aminopropionitrile and bis(cyanoethyl) amine. The mixture of aminonitriles is then hydrogenated in a downstream reactor over a fixed-bed catalyst (cobalt or nickel) at 60 – 120 ℃ to give 1,3-diaminopropane and bis (aminopropyl)amine. The yield of 1,3- diaminopropane can be increased by adding a polar solvent and water or by using a large excess of ammonia.

General Description

Water-white mobile liquid with an odor of amine.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

1,3-Diaminopropane is heat sensitive. 1,3-Diaminopropane may react with oxidizing agents.

Health Hazard

ACUTE/CHRONIC HAZARDS: 1,3-Diaminopropane is a strong irritant to eyes and skin: corrosive HAZARDOUS DECOMPOSITION PRODUCTS.

Fire Hazard

1,3-Diaminopropane is a flammable liquid.

Flammability and Explosibility

Flammable

Safety Profile

Poison by ingestion and skin contact. Experimental teratogenic effects. A severe skin and eye irritant. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.

Properties of 1,3-Diaminopropane

Melting point:	-12 °C
Boiling point:	140 °C(lit.)
Density	0.888 g/mL at 25 °C(lit.)
vapor pressure	<8 mm Hg ( 20 °C)
refractive index	n20/D 1.458(lit.)
Flash point:	120 °F
storage temp.	Store below +30°C.
solubility	DMSO (Slightly), Methanol (Slightly)
form	Liquid
pka	10.94(at 10℃)
color	Clear
PH	>12 (100g/l, H2O, 20℃)
explosive limit	2.8-15.2%(V)
Water Solubility	SOLUBLE
Sensitive	Air Sensitive
BRN	605277
Dielectric constant	9.6（Ambient）
Stability:	Stable. Hygroscopic. Flammable - readily forms explosive mixtures with air. Incompatible with acid anhydrides, acid chlorides, acids, strong oxidizing agents.
CAS DataBase Reference	109-76-2(CAS DataBase Reference)
NIST Chemistry Reference	1,3-Propanediamine(109-76-2)
EPA Substance Registry System	1,3-Diaminopropane (109-76-2)

Safety information for 1,3-Diaminopropane

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H226:Flammable liquids H290:Corrosive to Metals H302:Acute toxicity,oral H310:Acute toxicity,dermal H314:Skin corrosion/irritation H317:Sensitisation, Skin H334:Sensitisation, respiratory
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.