1,2,5,8-TETRAHYDROXYANTHRAQUINONE

Synonym(s):1,2,5,8- Tetra hydroxy-9,10- anthra quinone;1,2,5,8-Tetrahydroxy-9,10-anthraquinone;1,2,5,8-Tetrahydroxy-9,10-anthraquinone;1,2,5,8-Tetrahydroxyanthraquinone;Alizarin Bordeaux BD

CAS NO.：81-61-8
Empirical Formula: C14H8O6
Molecular Weight: 272.21
MDL number: MFCD00001205
EINECS: 201-366-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

1,2,5,8-TETRAHYDROXYANTHRAQUINONE Structural

What is 1,2,5,8-TETRAHYDROXYANTHRAQUINONE?

The Uses of 1,2,5,8-TETRAHYDROXYANTHRAQUINONE

1,2,5,8-TETRAHYDROXYANTHRAQUINONE is Al salts dark red, cotton mordanted with Cr salts bluish-violet. No longer used as a dye, except occasionally in printing cotton.

Definition

ChEBI: A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions.

Preparation

Quinalizarin. 1,2-Dihydroxyanthracene-9,10-dione or 1,4-Dihydroxyanthracene-9,10-dione with great excess fuming sulfuric acid oxidation and hydrolysis.

Biochem/physiol Actions

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Purification Methods

Crystallise the quinone from acetic acid or nitrobenzene. It can be sublimed in vacuo. The Cu salt forms red crystals. [Beilstein 8 H 549, 8 I 755, 8 II 584.]

Properties and Applications

violet (chromium), dark red light purple (aluminum). Soluble in ethanol. In concentrated sulfuric acid for blue purple, dilution after dark red precipitation.

Standard	Ironing Fastness	Light Fastness	Fulling		Persperation Fastness	Soaping	Water
			Alkali	Acid
ISO		6	4-5		5	4-5

Properties of 1,2,5,8-TETRAHYDROXYANTHRAQUINONE

Melting point:	≥300 °C
Boiling point:	375.27°C (rough estimate)
Density	1.4292 (rough estimate)
refractive index	1.5230 (estimate)
storage temp.	room temp
form	powder
Colour Index	58500
color	red
Water Solubility	2.586mg/L(25 ºC)
BRN	1889617
CAS DataBase Reference	81-61-8(CAS DataBase Reference)
EPA Substance Registry System	9,10-Anthracenedione, 1,2,5,8-tetrahydroxy- (81-61-8)

Safety information for 1,2,5,8-TETRAHYDROXYANTHRAQUINONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..…