1,2,4,5-Tetramethylbenzene

Synonym(s):1,2,4,5-Tetramethylbenzene;Durene;Durol, Durene

CAS NO.：95-93-2
Empirical Formula: C10H14
Molecular Weight: 134.22
MDL number: MFCD00008528
EINECS: 202-465-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:31

What is 1,2,4,5-Tetramethylbenzene?

Chemical properties

white to brown semi-transparent crystals

Physical properties

Colorless crystals or scales with a camphor-like odor

The Uses of 1,2,4,5-Tetramethylbenzene

1,2,4,5-Tetramethylbenzene is used in method for reducing odor in room in remodeling work by removing causative substances.

The Uses of 1,2,4,5-Tetramethylbenzene

Plasticizers; polymers; fibers; organic synthesis.

Definition

ChEBI: Durene is a tetramethylbenzene carrying methyl groups at positions 1, 2, 4 and 5.

General Description

Colorless crystals with a camphor-like odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic hydrocarbons, such as 1,2,4,5-Tetramethylbenzene, and strong oxidizing agents. They can react exothermically with bases and with diazo compounds. Substitution at the benzene nucleus occurs by halogenation (acid catalyst), nitration, sulfonation, and the Friedel-Crafts reaction.

Purification Methods

Chromatograph durene on alumina, and recrystallise it from aqueous EtOH or *benzene. Zone-refining removes duroaldehydes. Dry it under vacuum. [Yamauchi et al. J Phys Chem 89 4804 1985.] It has also been sublimed in vacuo [Johnston et al. J Am Chem Soc 109 1291 1987]. [Beilstein 5 H 431, 5 I 207, 5 II 329, 5 III 979, 5 IV 1076.]

Properties of 1,2,4,5-Tetramethylbenzene

Melting point:	78 °C
Boiling point:	196-197 °C
Density	0.838 g/mL at 25 °C(lit.)
vapor density	4.6 (vs air)
vapor pressure	160 mm Hg ( 140 °C)
refractive index	1.5093
Flash point:	165 °F
storage temp.	Flammables area
solubility	0.00348g/l
form	neat
color	White to Almost white
Specific Gravity	0.838
Odor	rancid sweet
Water Solubility	insoluble
Merck	14,3468
BRN	1903393
Henry's Law Constant	2.49 at 25 °C (approximate - calculated from water solubility and vapor pressure)
CAS DataBase Reference	95-93-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,2,4,5-tetramethyl-(95-93-2)
EPA Substance Registry System	1,2,4,5-Tetramethylbenzene (95-93-2)

Safety information for 1,2,4,5-Tetramethylbenzene

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Environment GHS09
GHS Hazard Statements	H228:Flammable solids H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction.