1,2,3-BENZOTRIAZIN-4(3H)-ONE

CAS NO.：90-16-4
Empirical Formula: C7H5N3O
Molecular Weight: 147.13
MDL number: MFCD00052387
EINECS: 201-971-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:22:46

What is 1,2,3-BENZOTRIAZIN-4(3H)-ONE?

Chemical properties

Tan powder. Soluble in alkaline solutions and organic bases.

The Uses of 1,2,3-BENZOTRIAZIN-4(3H)-ONE

1,2,3-Benzotriazin-4(3H)-one is part of a group of compounds that exhibit antimicrobial activity. 1,2,3-Benzotriazin-4(3H)-one is also used as a reagent to synthesize 1,2,3-Benzotriazin-4-one-arylpiperazine derivatives, compounds that act as Serotonin (HCl: S274980) receptor ligands.

The Uses of 1,2,3-BENZOTRIAZIN-4(3H)-ONE

Organic synthesis.

The Uses of 1,2,3-BENZOTRIAZIN-4(3H)-ONE

1,2,3-Benzotriazin-4(3H)one is used to prepare 3-methoxymethyl-3H-benzo[d][1,2,3]triazin-4-one by reacting with dimethoxymethane. Further, it undergoes thermal condensation with alfa-amino acids to give 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones. In addition to this, it is employed as a reagent to synthesize 1,2,3-bBenzotriazin-4-one-arylpiperazine derivatives.

Definition

Bicyclic.

General Description

1,2,3-Benzotriazin-4(3H)-one is an 1,2,3-benzotriazine derivative. 1,2,3-Benzotriazin-4(3H)-one undergoes thermal condensation with α-amino acids to yield 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones. 1,2,3-benzotriazin-4(3H)-one on thermolysis yields quinazolino[3,2-c][1,2,3]benzotriazin-8-one.

Safety Profile

Poison by intraperitoneal route.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx.

Properties of 1,2,3-BENZOTRIAZIN-4(3H)-ONE

Melting point:	216-218 °C (lit.)
Boiling point:	282℃
Density	1.47
refractive index	1.5500 (estimate)
Flash point:	125℃
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in most organic solvents.
form	Solid
pka	-4.67±0.20(Predicted)
color	Needles from cyclohexane
BRN	124996
CAS DataBase Reference	90-16-4(CAS DataBase Reference)
EPA Substance Registry System	1,2,3-Benzotriazin-4(1H)-one (90-16-4)

Safety information for 1,2,3-BENZOTRIAZIN-4(3H)-ONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.