1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

CAS NO.：509102-00-5
Empirical Formula: C17H21N3O3S
Molecular Weight: 347.43
MDL number: MFCD25563256
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-?

Description

MIM1 is an inhibitor of Mcl-1, an antiapoptotic Bcl-2 family protein with a role in cancer. It selectively engages the canonical groove of Mcl-1, inhibiting its ability to bind BH3 domains (IC₅₀ = 4.7 μM). MIM1 induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells.

The Uses of 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

MIM1 binds to MCL-1 and aids in the modulation of cell death, division and differentiation. MIM1 may be used for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders.

References

[1]. cohen na, stewart ml, gavathiotis e, et al. a competitive stapled peptide screen identifies a selective small molecule that overcomes mcl-1-dependent leukemia cell survival. chemistry & biology, 2012, 19(9): 1175-1186.

Properties of 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

Boiling point:	559.6±60.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
solubility	insoluble in EtOH; insoluble in H2O; ≥12.15 mg/mL in DMSO
pka	7.73±0.45(Predicted)
form	A crystalline solid
color	White to off-white

Safety information for 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

Computed Descriptors for 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

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