1,2,2,6,6-Pentamethylpiperidine

Synonym(s):Pempidine;PMP

CAS NO.：79-55-0
Empirical Formula: C10H21N
Molecular Weight: 155.28
MDL number: MFCD00006493
EINECS: 201-211-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:52:50

1,2,2,6,6-Pentamethylpiperidine Structural

What is 1,2,2,6,6-Pentamethylpiperidine?

Chemical properties

CLEAR COLORLESS TO LIGHT YELLOW LIQUID

The Uses of 1,2,2,6,6-Pentamethylpiperidine

1,2,2,6,6-Pentamethylpiperidine is used in the synthesis of BN-fused polycyclic aromatic molecules for potential application to electronic materials and apparatus. In addition, it is a catalyst for th e chemoselective silylation of benzylic alcohols.

The Uses of 1,2,2,6,6-Pentamethylpiperidine

ganglionic blocker, antihypertensive

The Uses of 1,2,2,6,6-Pentamethylpiperidine

Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine where pempidine was found to increase the ED50 of nicotine (0.73 mg/kg) for depression of spontaneous activity in a dose-related manner. At a dose of 3 mg/kg, pempidine increased nicotine's ED50 4.7-fold.

Definition

ChEBI: 1,2,2,6,6-pentamethylpiperidine is a member of piperidines.

General Description

The focal 1,8-naphthalimide fluorophores in the antennae were modified with 1,2,2,6,6-pentamethylpiperidine to improve their photostability.

Safety Profile

Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.

Properties of 1,2,2,6,6-Pentamethylpiperidine

Melting point:	<25 °C
Boiling point:	187-188 °C(lit.)
Density	0.858 g/mL at 25 °C(lit.)
refractive index	n20/D 1.460(lit.)
Flash point:	122 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in toluene, dimethylformamide.
form	Liquid
pka	11.25(at 30℃)
color	Clear colorless to light yellow
Sensitive	Air Sensitive
Merck	14,7080
BRN	103806
CAS DataBase Reference	79-55-0(CAS DataBase Reference)
EPA Substance Registry System	Piperidine, 1,2,2,6,6-pentamethyl- (79-55-0)

Safety information for 1,2,2,6,6-Pentamethylpiperidine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H226:Flammable liquids H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.