1,2,2,6,6-PENTAMETHYLPIPERIDINE
Synonym(s):Pempidine;PMP
- CAS NO.：79-55-0
- Empirical Formula: C10H21N
- Molecular Weight: 155.28
- MDL number: MFCD00006493
- EINECS: 201-211-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is 1,2,2,6,6-PENTAMETHYLPIPERIDINE?
Chemical properties
CLEAR COLORLESS TO LIGHT YELLOW LIQUID
The Uses of 1,2,2,6,6-PENTAMETHYLPIPERIDINE
1,2,2,6,6-Pentamethylpiperidine is used in the synthesis of BN-fused polycyclic aromatic molecules for potential application to electronic materials and apparatus. In addition, it is a catalyst for th e chemoselective silylation of benzylic alcohols.
The Uses of 1,2,2,6,6-PENTAMETHYLPIPERIDINE
ganglionic blocker, antihypertensive
The Uses of 1,2,2,6,6-PENTAMETHYLPIPERIDINE
Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine where pempidine was found to increase the ED50 of nicotine (0.73 mg/kg) for depression of spontaneous activity in a dose-related manner. At a dose of 3 mg/kg, pempidine increased nicotine's ED50 4.7-fold.
Definition
ChEBI: 1,2,2,6,6-pentamethylpiperidine is a member of piperidines.
General Description
The focal 1,8-naphthalimide fluorophores in the antennae were modified with 1,2,2,6,6-pentamethylpiperidine to improve their photostability.
Safety Profile
Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Properties of 1,2,2,6,6-PENTAMETHYLPIPERIDINE
| Melting point: | <25 °C |
| Boiling point: | 187-188 °C(lit.) |
| Density | 0.858 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 122 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in toluene, dimethylformamide. |
| form | Liquid |
| pka | 11.25(at 30℃) |
| color | Clear colorless to light yellow |
| Sensitive | Air Sensitive |
| Merck | 14,7080 |
| BRN | 103806 |
| CAS DataBase Reference | 79-55-0(CAS DataBase Reference) |
| EPA Substance Registry System | Piperidine, 1,2,2,6,6-pentamethyl- (79-55-0) |
Safety information for 1,2,2,6,6-PENTAMETHYLPIPERIDINE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H226:Flammable liquids H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,2,2,6,6-PENTAMETHYLPIPERIDINE
| InChIKey | XULIXFLCVXWHRF-UHFFFAOYSA-N |
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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