10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
Synonym(s):10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide;10,11-Dihydro-10-hydroxycarbamazepine;Licarbazepine
- CAS NO.：29331-92-8
- Empirical Formula: C15H14N2O2
- Molecular Weight: 254.28
- MDL number: MFCD00871817
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:25
What is 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE?
Chemical properties
White Solid
The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
A metabolite of Oxcarbazepine
The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
A labelled metabolite of Oxcarbazepine
The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
10,11-dihydro-10-hydroxy Carbamazepinee is the active metabolite of oxcarbazepine . Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors. ?10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release.
What are the applications of Application
10,11-Dihydro-10-hydroxy carbamazepine is a sodium channel protein inhibitor
Definition
ChEBI: A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel b ocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine.
Storage
Store at RT
Properties of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
| Melting point: | 186-189°C |
| Boiling point: | 431.3±55.0 °C(Predicted) |
| Density | 1.336 |
| Flash point: | 2℃ |
| storage temp. | -20°C |
| solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| form | neat |
| pka | 13.75±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| BRN | 1540211 |
| CAS DataBase Reference | 29331-92-8 |
Safety information for 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
| Signal word | Danger |
| Pictogram(s) |
 Environment GHS09 |
| GHS Hazard Statements |
H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P501:Dispose of contents/container to..… |
Computed Descriptors for 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
| InChIKey | BMPDWHIDQYTSHX-UHFFFAOYSA-N |
10,11-DIHYDRO-10-HYDROXYCARBAZEPINE manufacturer
Besil Chem LLP
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