1-Tetralone
Synonym(s):α-Tetralone;1,2,3,4-Tetrahydro-1-naphthalenone;3,4-Dihydro-1(2H)-naphthalenone;alpha-Tetralone
- CAS NO.：529-34-0
- Empirical Formula: C10H10O
- Molecular Weight: 146.19
- MDL number: MFCD00001688
- EINECS: 208-460-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:02
What is 1-Tetralone?
Chemical properties
Clear amber to brown oily liquid
The Uses of 1-Tetralone
1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.
Synthesis Reference(s)
Tetrahedron Letters, 32, p. 4291, 1991 DOI: 10.1016/S0040-4039(00)92151-8
Purification Methods
Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.]
Properties of 1-Tetralone
| Melting point: | 2-7 °C(lit.) |
| Boiling point: | 113-116 °C6 mm Hg(lit.) |
| Density | 1.099 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Liquid |
| color | brown |
| Water Solubility | insoluble |
| BRN | 607374 |
| CAS DataBase Reference | 529-34-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1(2H)-Naphthalenone, 3,4-dihydro-(529-34-0) |
| EPA Substance Registry System | 1,2,3,4-Tetrahydronaphthalen-1-one (529-34-0) |
Safety information for 1-Tetralone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 1-Tetralone
| InChIKey | XHLHPRDBBAGVEG-UHFFFAOYSA-N |
1-Tetralone manufacturer
BTC pharm India
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