1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
Synonym(s):1-( iso-Propyl)-1H-benzotriazole-5-carboxylic acid;1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid;GPR109b Agonist - CAS 306935-41-1 - Calbiochem
- CAS NO.：306935-41-1
- Empirical Formula: C10H11N3O2
- Molecular Weight: 205.21
- MDL number: MFCD01570664
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-07 19:09:50
What is 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID?
Description
IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a.
What are the applications of Application
IBC 293 is a selective HM74/GPR109b receptor agonist
Definition
ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles.
Biological Activity
Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes.
References
1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227
Properties of 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
| Melting point: | 229-230°C |
| Boiling point: | 413.9±18.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Light brown solid |
| pka | 3.50±0.30(Predicted) |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 306935-41-1(CAS DataBase Reference) |
Safety information for 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
Computed Descriptors for 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
New Products
4,4-Difluoropiperidine hydrochloride tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin N-Isopropylurea N,N-Dicyclohexylcarbodiimide(DCC) MELDRUMS ACID 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID Magnessium Bis glycinate Zinc ascorbate 1-bromo-2-butyne 2-acetamidophenol 9(10H)-anthracenone Erythrosin B, 4-Piperidinopiperidine 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 2-(benzylamino)acetic acid hydrochloride 4-(tert-Butoxycarbonylamino)but- 2-ynoic acid 3,4-dihydro-2H-benzo[b][1,4]dioxepine 1-Phenyl-1-cycloprppanecarboxylicacidRelated products of tetrahydrofuran
You may like
-
1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid CASView Details -
3-(4-amino-1-oxoisoindolin-2-yl)-1-methylpiperidine-2,6-dione 98%View Details
-
614-19-7 98%View Details
614-19-7 -
3112-85-4 Methyl phenyl sulfone 98%View Details
3112-85-4 -
20677-73-0 (2,2-diethoxyethyl)methylamine 98%View Details
20677-73-0 -
3-(4-(hydroxyamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 98%View Details
-
57381-49-4 2-bromo-4-chlorobenzonitrile 98%View Details
57381-49-4 -
4,6-dichloropyrimidine-5-carbaldehyde 98%View Details
5305-40-8