1'-HYDROXYMIDAZOLAM
Synonym(s):8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine
- CAS NO.：59468-90-5
- Empirical Formula: C18H13ClFN3O
- Molecular Weight: 341.77
- MDL number: MFCD00871458
- EINECS: 200-659-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:02:00
What is 1'-HYDROXYMIDAZOLAM?
Description
1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.
Chemical properties
White Solid
The Uses of 1'-HYDROXYMIDAZOLAM
CYP3A4 metabolite of midazolam
The Uses of 1'-HYDROXYMIDAZOLAM
A metabolite of Midazolam (M343000).
Definition
ChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam.
Properties of 1'-HYDROXYMIDAZOLAM
| Melting point: | 264-266oC |
| Boiling point: | 540.6±60.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMF: 2 mg/ml; DMSO: 1 mg/ml |
| form | A crystalline solid |
| pka | 13.59±0.10(Predicted) |
| color | white or off-white |
Safety information for 1'-HYDROXYMIDAZOLAM
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 1'-HYDROXYMIDAZOLAM
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2-Bromo-5-hydroxybenzoic acid. 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile 5-Amino-2-Hydroxypyridine 2-Amino-5-Iodopyridine 2-BROMOACETYL BROMIDE-D2 METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 6-Chloro-pyrimidine-2,4-diamine 3-Oxide 1-Acetyl-4-(4-hydroxyphenyl)piperazine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
![1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 5-OXIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure8/GIF/CB4411594.gif)
![1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE](https://img.chemicalbook.in/CAS/GIF/59468-89-2.gif)
![a-Hydroxymidazolam-13C3, 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine-13C3,,1'-HYDROXYMIDAZOLAM-13C3](https://img.chemicalbook.in/CAS/20140608/GIF/CB3649161.gif)
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