1-HYDROXY-1-CYCLOHEXANECARBONITRILE
Synonym(s):1-Hydroxy-1-cyclohexanecarbonitrile
- CAS NO.：931-97-5
- Empirical Formula: C7H11NO
- Molecular Weight: 125.17
- MDL number: MFCD00003818
- EINECS: 213-246-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is 1-HYDROXY-1-CYCLOHEXANECARBONITRILE?
The Uses of 1-HYDROXY-1-CYCLOHEXANECARBONITRILE
Cyclohexanone cyanohydrin was employed as substrate during high-throughput screening assay for hydroxynitrile lyase activity. It was used in preparation of 1-aminomethyl cyclohexanol via catalytic hydrogenation reaction.
Synthesis Reference(s)
Tetrahedron Letters, 19, p. 3773, 1978 DOI: 10.1016/S0040-4039(01)95055-5
General Description
Brown solid.
Air & Water Reactions
Water soluble. Reacts slowly with water .
Reactivity Profile
1-HYDROXY-1-CYCLOHEXANECARBONITRILE is an a-hydroxonitrile. Incompatible with acids; mixing nitriles with strong oxidizing acids can lead to violent reactions. Incompatible with oxidizing agents such as peroxides and epoxides. Mixing with bases can produce poisonous and flammable hydrogen cyanide. May be hydrolyzed exothermically in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). May react vigorously with reducing agents.
Fire Hazard
Flash point data regarding 1-HYDROXY-1-CYCLOHEXANECARBONITRILE are not available, however, 1-HYDROXY-1-CYCLOHEXANECARBONITRILE is probably combustible.
Properties of 1-HYDROXY-1-CYCLOHEXANECARBONITRILE
| Melting point: | 32-35 °C (lit.) |
| Boiling point: | 132 °C/19 mmHg (lit.) |
| Density | 1.031 |
| refractive index | 1.4693 |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| pka | 11.45±0.20(Predicted) |
| CAS DataBase Reference | 931-97-5(CAS DataBase Reference) |
| EPA Substance Registry System | Cyclohexanone cyanohydrin (931-97-5) |
Safety information for 1-HYDROXY-1-CYCLOHEXANECARBONITRILE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H300:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 1-HYDROXY-1-CYCLOHEXANECARBONITRILE
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