1-Ethylpiperazine

Synonym(s):1-Ethylpiperazine

CAS NO.：5308-25-8
Empirical Formula: C6H14N2
Molecular Weight: 114.19
MDL number: MFCD00059912
EINECS: 226-166-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:23:55

What is 1-Ethylpiperazine?

Chemical properties

clear colorless to yellow liquid

The Uses of 1-Ethylpiperazine

1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.

The Uses of 1-Ethylpiperazine

1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 713, 1957 DOI: 10.1021/jo01357a621

Flammability and Explosibility

Flammable

Properties of 1-Ethylpiperazine

Melting point:	-60 °C
Boiling point:	157 °C(lit.)
Density	0.899 g/mL at 25 °C(lit.)
vapor pressure	2.48hPa at 20℃
refractive index	n20/D 1.469(lit.)
Flash point:	110 °F
storage temp.	2-8°C
solubility	soluble
form	Liquid
pka	9.27±0.10(Predicted)
Specific Gravity	0.899
color	Clear colorless to yellow
Water Solubility	soluble
Sensitive	Air Sensitive
BRN	102971
CAS DataBase Reference	5308-25-8(CAS DataBase Reference)
NIST Chemistry Reference	N-ethylpiperazine(5308-25-8)
EPA Substance Registry System	Piperazine, 1-ethyl- (5308-25-8)

Safety information for 1-Ethylpiperazine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation H317:Sensitisation, Skin H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.