1-Chloro-4-fluorobenzene
- CAS NO.：352-33-0
- Empirical Formula: C6H4ClF
- Molecular Weight: 130.55
- MDL number: MFCD00000603
- EINECS: 206-521-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 1-Chloro-4-fluorobenzene?
Chemical properties
Clear colourless to light yellow liquid
The Uses of 1-Chloro-4-fluorobenzene
1-Chloro-4-fluorobenzeneis used as a primary and secondary intermediates, organic synthesis. And it is also used to prepare (4'-fluoro-biphenyl-4-yl)-methyl ether by using reagents NaH, Ni (OAc)2, 2,2 '-bipyridyl, KI and solvents benzene, tetrahydrofuran at temperature of 63°C.
Properties of 1-Chloro-4-fluorobenzene
| Melting point: | -21.5 °C |
| Boiling point: | 129-130 °C(lit.) |
| Density | 1.226 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 85 °F |
| storage temp. | Flammables area |
| solubility | Difficult to mix. |
| form | Liquid |
| color | Clear colorless to slightly yellow |
| Specific Gravity | 1.226 |
| BRN | 1904542 |
| CAS DataBase Reference | 352-33-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-chloro-4-fluoro-(352-33-0) |
| EPA Substance Registry System | Benzene, 1-chloro-4-fluoro- (352-33-0) |
Safety information for 1-Chloro-4-fluorobenzene
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Chloro-4-fluorobenzene
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