1-Boc-4-(aminomethyl)piperidine

Synonym(s):N-(tert-Butoxycarbonyl)-4-aminomethylpiperidine;1,1-Dimethylethyl 4-(aminomethyl)-1-piperidinecarboxylate

CAS NO.：144222-22-0
Empirical Formula: C11H22N2O2
Molecular Weight: 214.31
MDL number: MFCD01076207
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:06:22

1-Boc-4-(aminomethyl)piperidine Structural

What is 1-Boc-4-(aminomethyl)piperidine?

Chemical properties

White Low Melting Solid

The Uses of 1-Boc-4-(aminomethyl)piperidine

1-Boc-4-(aminomethyl)piperidine is a protected 4-substituted piperidinecarboxylate used in the preparation of orally active platelet-activating factor antagonists as well as other biologically active compounds.

The Uses of 1-Boc-4-(aminomethyl)piperidine

1-Boc-4-(aminomethyl)piperidine is used in the preparation biologically active compounds and orally active platelet-activating factor antagonists. It is used as an inhibitor for Kinesin spindle protein. It is an active reactant involved in the enantioselective synthesis of N-alkyl terminal aziridines.Precursor in the preparation of a variety of different protein agonists or antagonists including: Orphan G-protein coupled receptor GPR119 agonist with antidiabetic potential, Pim-1 inhibitors, and Aspartic acid protease inhibitors.

Properties of 1-Boc-4-(aminomethyl)piperidine

Boiling point:	237-238 °C(lit.)
Density	1.013 g/mL at 25 °C(lit.)
refractive index	n20/D 1.473(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in chloroform and methanol.
pka	10.13±0.29(Predicted)
form	Liquid or Low Melting Solid
color	Colorless to yellow
InChI	InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-8,12H2,1-3H3
CAS DataBase Reference	144222-22-0(CAS DataBase Reference)

Safety information for 1-Boc-4-(aminomethyl)piperidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.