1-Benzylimidazole

CAS NO.：4238-71-5
Empirical Formula: C10H10N2
Molecular Weight: 158.2
MDL number: MFCD00005296
EINECS: 224-200-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-06-26 15:55:04

What is 1-Benzylimidazole?

Chemical properties

BROWNISH CRYSTALS

The Uses of 1-Benzylimidazole

1-Benzylimidazole acts as an inducer of various cytochrome P-450 isozymes and inhibitor of thromboxane A2 synthase. 1-Benzylimidazole has been used to prepare cyclodextrin-ionic liquid polymer (βCD-BIMOTs-TDI)

The Uses of 1-Benzylimidazole

Sodium thiosulfate pentahydrate may be involved in the estimation of iodide in pharmaceutical samples, using spectrophotometric method.

What are the applications of Application

Benzylimidazole is an inducer of various cytochrome P-450 isozymes and inhibitor of thromboxane A2 synthase

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 383, 1949 DOI: 10.1021/ja01170a002

General Description

1-Benzylimidazole has been used to prepare cyclodextrin-ionic liquid polymer (βCD-BIMOTs-TDI).

Biochem/physiol Actions

1-Benzylimidazole is a CYP inhibitor that inhibits the biotransformation of MeO-BDEs (methoxylated-brominated diphenyl ethers) to OH-BDEs (hydroxylated) in fishes.

Properties of 1-Benzylimidazole

Melting point:	68-70 °C(lit.)
Boiling point:	310 °C(lit.)
Density	1.2419 (rough estimate)
refractive index	1.6392 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMF: >530 μg/ml; DMSO: >560 μg/ml; Ethanol: >500 μg/ml; PBS pH 7.2: >6.5 mg/ml
pka	6.79±0.10(Predicted)
form	Crystals
color	Brownish
Water Solubility	insoluble
λmax	215nm(EtOH)(lit.)
BRN	114571
CAS DataBase Reference	4238-71-5(CAS DataBase Reference)
NIST Chemistry Reference	1H-Imidazole, 1-(phenylmethyl)-(4238-71-5)

Safety information for 1-Benzylimidazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.