1-Acetylpiperazine
- CAS NO.：13889-98-0
- Empirical Formula: C6H12N2O
- Molecular Weight: 128.17
- MDL number: MFCD00058676
- EINECS: 237-659-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:56
What is 1-Acetylpiperazine?
Chemical properties
clear light yellow liquid after melting
The Uses of 1-Acetylpiperazine
1-Acetylpiperazine may be used in the synthesis of series of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives and 2-substituted-N-(naphth-1-ylmethyl)-pyrimidin-4-amines and 2-substituted-N-benzhydrylpyrimidin-4-amines.
Definition
ChEBI: 1-Acetylpiperazine is a member of phytanoyl-CoAs.
General Description
Infrared and Raman spectra of 1-acetylpiperazine have been recorded in the region of 4000-40cm-1.
Purification Methods
Purify 1-acetylpiperazine by recrystallisation from 40% aqueous EtOH or from EtOH/Et2O. It is an irritant, and is hygroscopic. The hydrochloride has m 191o (from EtOH), and the tosylate salt has m 148-149o (from EtOH/EtOAc, 1:16). The free base, however, cannot be isolated by basifying the tosylate salt and extraction with CH2Cl2. [Jacobi Chem Ber 66 113 1933, Mosher et al. J Am Chem Soc 75 4949 1953, Hall J Am Chem Soc 78 2570 1956, Beilstein 23 IV 1786.]
Properties of 1-Acetylpiperazine
| Melting point: | 31-34 °C (lit.) |
| Boiling point: | 127 °C |
| Density | 1.0754 (rough estimate) |
| refractive index | 1.4880 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | methanol: soluble1g/10 mL, clear, colorless to faintly greenish-yellow |
| form | Liquid After Melting |
| pka | 8.50±0.10(Predicted) |
| color | Clear light yellow |
| Water Solubility | Soluble in water 210 g/L (20°C). |
| Sensitive | Hygroscopic |
| BRN | 112220 |
| CAS DataBase Reference | 13889-98-0(CAS DataBase Reference) |
Safety information for 1-Acetylpiperazine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H314:Skin corrosion/irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for 1-Acetylpiperazine
1-Acetylpiperazine manufacturer
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