1-Acetylpiperazine

CAS NO.：13889-98-0
Empirical Formula: C6H12N2O
Molecular Weight: 128.17
MDL number: MFCD00058676
EINECS: 237-659-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:59:00

What is 1-Acetylpiperazine?

Chemical properties

clear light yellow liquid after melting

The Uses of 1-Acetylpiperazine

1-Acetylpiperazine may be used in the synthesis of series of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives and 2-substituted-N-(naphth-1-ylmethyl)-pyrimidin-4-amines and 2-substituted-N-benzhydrylpyrimidin-4-amines.

Definition

ChEBI: 1-Acetylpiperazine is a member of phytanoyl-CoAs.

General Description

Infrared and Raman spectra of 1-acetylpiperazine have been recorded in the region of 4000-40cm^-1.

Purification Methods

Purify 1-acetylpiperazine by recrystallisation from 40% aqueous EtOH or from EtOH/Et2O. It is an irritant, and is hygroscopic. The hydrochloride has m 191o (from EtOH), and the tosylate salt has m 148-149o (from EtOH/EtOAc, 1:16). The free base, however, cannot be isolated by basifying the tosylate salt and extraction with CH2Cl2. [Jacobi Chem Ber 66 113 1933, Mosher et al. J Am Chem Soc 75 4949 1953, Hall J Am Chem Soc 78 2570 1956, Beilstein 23 IV 1786.]

Properties of 1-Acetylpiperazine

Melting point:	31-34 °C (lit.)
Boiling point:	127 °C
Density	1.0754 (rough estimate)
refractive index	1.4880 (estimate)
Flash point:	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	methanol: soluble1g/10 mL, clear, colorless to faintly greenish-yellow
form	Liquid After Melting
pka	8.50±0.10(Predicted)
color	Clear light yellow
Water Solubility	Soluble in water 210 g/L (20°C).
Sensitive	Hygroscopic
BRN	112220
CAS DataBase Reference	13889-98-0(CAS DataBase Reference)

Safety information for 1-Acetylpiperazine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H314:Skin corrosion/irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.