1-(5-Chloro-2-hydroxyphenyl)ethanone
- CAS NO.：1450-74-4
- Empirical Formula: C8H7ClO2
- Molecular Weight: 170.59
- MDL number: MFCD00067788
- EINECS: 215-916-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:13:42
What is 1-(5-Chloro-2-hydroxyphenyl)ethanone?
Chemical properties
slightly yellow crystalline powder or chunks
The Uses of 1-(5-Chloro-2-hydroxyphenyl)ethanone
5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) may be used in the synthesis of:
- 6-chloro-2-methyl-4H-chrome-4-one
- 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
- 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
- 2-styrenyl allyl ether
Preparation
Preparation by Fries rearrangement of 4-chlorophenyl acetate with aluminium chloride without solvent between 110° and 200°(90–100% yield).
General Description
5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) on condensation with salicylhydrazide yields Schiff base, which is reported to form copper(II) complexes. Dipole moment of 5-chloro-2- hydroxyacetophenone has been evaluated in benzene solution.
Properties of 1-(5-Chloro-2-hydroxyphenyl)ethanone
| Melting point: | 54-56 °C(lit.) |
| Boiling point: | 126-128 °C28 mm Hg(lit.) |
| Density | 1.2315 (rough estimate) |
| refractive index | 1.5590 (estimate) |
| Flash point: | 107-109°C/12mm |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 9.72±0.18(Predicted) |
| form | Solid |
| BRN | 1365589 |
| CAS DataBase Reference | 1450-74-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(5-chloro-2-hydroxyphenyl)-(1450-74-4) |
Safety information for 1-(5-Chloro-2-hydroxyphenyl)ethanone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(5-Chloro-2-hydroxyphenyl)ethanone
| InChIKey | XTGCUDZCCIRWHL-UHFFFAOYSA-N |
1-(5-Chloro-2-hydroxyphenyl)ethanone manufacturer
New Products
Methyl 2-hydroxy-3-nitrobenzoate 1,3-Diethyl-1,3-Diphenylurea 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 3-Hydroxy-4-nitrobromobenzene 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Thio AcetamideRelated products of tetrahydrofuran
![METHYL 7-CHLORO-2-ETHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB4688668.gif)
You may like
-
5’-Chloro-2’-hydroxyacetophenone 98%View Details
1450-74-4 -
1450-74-4 5’-Chloro-2’-Hydroxyacetophenone 98%View Details
1450-74-4 -
5'-Chloro-2'-hydroxyacetophenone 98%View Details
1450-74-4 -
5'-Chloro-2'-hydroxyacetophenone 1450-74-4 98%View Details
1450-74-4 -
1450-74-4 98%View Details
1450-74-4 -
5′-Chloro-2′-hydroxyacetophenone, 99% CAS 1450-74-4View Details
1450-74-4 -
5′-Chloro-2′-hydroxyacetophenone CAS 1450-74-4View Details
1450-74-4 -
5-Chloro-2-HydroxyacetophenoneView Details
1450-74-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.