1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE

The Uses of 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE

Oncrasin 1 is a proapoptotic compound.

What are the applications of Application

Oncrasin 1 is a proapoptotic compound

Definition

ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.

Biological Activity

Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .

Storage

+4°C