1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
Synonym(s):1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride;Nefazodone Related Compound A;Trazodone Impurity F (Ph. Eur.)
- CAS NO.：52605-52-4
- Empirical Formula: C13H19Cl3N2
- Molecular Weight: 309.66
- MDL number: MFCD00067039
- EINECS: 258-038-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-10 17:37:39
What is 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride?
Chemical properties
Off-White Solid
The Uses of 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride is an arylpiperazine compound which is an important intermediate in the preparation of various pharmaceuticals, such as Trazodone (T718500), used to treat depression and post-traumatic stress.
General Description
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is present as impurity in nefazodone hydrochloride (pharmaceutical formulation). Synthesis of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is reported.
Flammability and Explosibility
Not classified
Properties of 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
| Melting point: | 198-203 °C(lit.) |
| Boiling point: | 147℃[at 101 325 Pa] |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
| form | powder to crystal |
| color | White to Light yellow |
| Water Solubility | 3.9g/L at 28℃ |
| CAS DataBase Reference | 52605-52-4(CAS DataBase Reference) |
Safety information for 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
| InChIKey | JVLRNANYLVRULL-UHFFFAOYSA-N |
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride manufacturer
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product: 1- (3-Chlorophenyl)-4- (3-Chloropropyl)-Piperazine Hydrochloride
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