1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Description

TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2

The Uses of 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.

What are the applications of Application

TRIM is a NOS1 (nNOS) and NOS2 (iNOS) inhibitor

Definition

ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .

Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

References

1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423