1-(2-Chloroethyl)pyrrolidine Hydrochloride

Synonym(s):2-Pyrrolidinoethyl chloride hydrochloride

CAS NO.：7250-67-1
Empirical Formula: C6H13Cl2N
Molecular Weight: 170.08
MDL number: MFCD00012718
EINECS: 230-660-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:19:22

1-(2-Chloroethyl)pyrrolidine Hydrochloride Structural

What is 1-(2-Chloroethyl)pyrrolidine Hydrochloride?

Chemical properties

white to off-white crystals or crystalline powder

The Uses of 1-(2-Chloroethyl)pyrrolidine Hydrochloride

1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its ana logues.

The Uses of 1-(2-Chloroethyl)pyrrolidine Hydrochloride

Purification Methods

Purify the hydrochloride by recrystallisation from isopropanol/di-isopropyl ether (charcoal) and recrystallise it twice more. The free base, b 55-56o/11mm, 60-63o/23mm and 90o/56mm, is relatively unstable and should be converted to the hydrochloride immediately, by dissolving in isopropanol and bubbling dry HCl through the solution at 0o, filtering off the hydrochloride and recrystallising it. The picrate has m 107.3-107.8o (from EtOH) [Cason J Org Chem 24 247 1959, Wright et al. J Am Chem Soc 70 3098 1948]. [Beilstein 20 III/IV 66.]

Properties of 1-(2-Chloroethyl)pyrrolidine Hydrochloride

Melting point:	167-170 °C(lit.)
Boiling point:	237°C(lit.)
Density	0.4[at 20℃]
vapor pressure	1.64hPa at 25℃
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Water (Slightly)
form	Crystalline Powder or Crystals
color	White to off-white
Water Solubility	Soluble
Sensitive	Hygroscopic
BRN	3677061
InChI	InChI=1S/C6H12ClN.ClH/c7-3-6-8-4-1-2-5-8;/h1-6H2;1H
CAS DataBase Reference	7250-67-1(CAS DataBase Reference)

Safety information for 1-(2-Chloroethyl)pyrrolidine Hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.