(+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
Synonym(s):trans-Cyclohexane-1,2-dicarboxylic acid anhydride;trans-Hexahydro-1,3-isobenzofurandione;trans-Hexahydrophthalic anhydride
- CAS NO.：14166-21-3
- Empirical Formula: C8H10O3
- Molecular Weight: 154.16
- MDL number: MFCD00064345
- EINECS: 238-009-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE?
The Uses of (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
Trans-1,2-cyclohexanedicarboxylic anhydride can be used as a reagent to prepare hepatitis C virus (HCV) and granzyme B (indoline derivatives) inhibitors. It has also been employed in studies relating to the development of protein kinase C inhibitors.
Purification Methods
Crystallise the anhydride from *C6H6/Et2O. It has been obtained by heating the cis-acid or anhydride with HCl at 180o for 3hours. It can be obtained from the acid by heating in Ac2O. It sublimes at 125-135o/0.02mm. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Fichter & Simon Helv Chim Acta 17 1218 1934, Beilstein 9 IV 2802.]
Properties of (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
| Melting point: | 145-147 °C(lit.) |
| Boiling point: | 283.4±0.0 °C(Predicted) |
| Density | 1.235±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetone (Sparingly), Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| color | White to Pale Beige |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 14166-21-3 |
Safety information for (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..… |
Computed Descriptors for (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
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