(+/-)-LY367385
- CAS NO.：198419-90-8
- Empirical Formula: C10H11NO4
- Molecular Weight: 209.2
- MDL number: MFCD10565942
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is (+/-)-LY367385?
Description
(±)-LY367385 is an antagonist of metabotropic glutamate receptor 1α (mGluR1α).1 It inhibits phosphoinositide (PI) hydrolysis selectively in AV-12 cells expressing mGluR1α over those expressing mGluR5a (IC50s = 19 and >300 μM, respectively).
References
1. Salt, T.E., Jones, H.E., Copeland, C.S., et al. Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus Neuropharmacology 79(100),405-411(2014).
Properties of (+/-)-LY367385
| Boiling point: | 434.0±45.0 °C(Predicted) |
| Density | 1.393±0.06 g/cm3(Predicted) |
| solubility | Water: 20 mg/ml |
| form | A solid |
| pka | 1.72±0.10(Predicted) |
| color | White to off-white |
Safety information for (+/-)-LY367385
Computed Descriptors for (+/-)-LY367385
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) BOC Piperazine 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 Trans,trans muconic acid HC Blue-16 4-Amino-2-chloro-6,7-dimethoxyquinazoline Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 2,3-Dimethoxypyridine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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