(+/-)-LY367385
- CAS NO.：198419-90-8
- Empirical Formula: C10H11NO4
- Molecular Weight: 209.2
- MDL number: MFCD10565942
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is (+/-)-LY367385?
Description
(±)-LY367385 is an antagonist of metabotropic glutamate receptor 1α (mGluR1α).1 It inhibits phosphoinositide (PI) hydrolysis selectively in AV-12 cells expressing mGluR1α over those expressing mGluR5a (IC50s = 19 and >300 μM, respectively).
References
1. Salt, T.E., Jones, H.E., Copeland, C.S., et al. Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus Neuropharmacology 79(100),405-411(2014).
Properties of (+/-)-LY367385
| Boiling point: | 434.0±45.0 °C(Predicted) |
| Density | 1.393±0.06 g/cm3(Predicted) |
| solubility | Water: 20 mg/ml |
| form | A solid |
| pka | 1.72±0.10(Predicted) |
| color | White to off-white |
Safety information for (+/-)-LY367385
Computed Descriptors for (+/-)-LY367385
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