(+)-ALPHA-DIHYDROTETRABENAZINE
- CAS NO.：3466-75-9
- Empirical Formula: C19H29NO3
- Molecular Weight: 319.44
- MDL number: MFCD20275194
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-18 09:51:34
What is (+)-ALPHA-DIHYDROTETRABENAZINE?
Description
Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.
Chemical properties
Colourless solid
Definition
ChEBI: B-Dihydrotetrabenazine is a member of isoquinolines.
Properties of (+)-ALPHA-DIHYDROTETRABENAZINE
| Boiling point: | 457.8±45.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Chloroform: soluble; Methanol: soluble |
| form | A solid |
| pka | 14.75±0.40(Predicted) |
| CAS DataBase Reference | 3466-75-9 |
Safety information for (+)-ALPHA-DIHYDROTETRABENAZINE
Computed Descriptors for (+)-ALPHA-DIHYDROTETRABENAZINE
New Products
4,4-Difluoropiperidine hydrochloride tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin N-Isopropylurea N,N-Dicyclohexylcarbodiimide(DCC) MELDRUMS ACID 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID Magnessium Bis glycinate Zinc ascorbate 1-bromo-2-butyne 2-acetamidophenol 9(10H)-anthracenone Erythrosin B, 4-Piperidinopiperidine 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 2-(benzylamino)acetic acid hydrochloride 4-(tert-Butoxycarbonylamino)but- 2-ynoic acid 3,4-dihydro-2H-benzo[b][1,4]dioxepine 1-Phenyl-1-cycloprppanecarboxylicacidRelated products of tetrahydrofuran
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