α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
Synonym(s):α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine;CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI;Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
- CAS NO.：305372-78-5
- Empirical Formula: C21H18ClN3
- Molecular Weight: 347.84
- MDL number: MFCD01831143
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine?
The Uses of α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
What are the applications of Application
CCT036477 is an inhibitor of Wnt signaling
Definition
ChEBI: N-[(4-chlorophenyl)-(2-methyl-1H-indol-3-yl)methyl]-2-pyridinamine is a member of indoles.
Properties of α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
| Melting point: | >167°C (dec.) |
| Boiling point: | 546.0±45.0 °C(Predicted) |
| Density | 1.301±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥20mg/mL (warm to 60°C) |
| pka | 17.33±0.30(Predicted) |
| form | powder |
| color | white to tan |
| Stability: | Light Sensitive |
Safety information for α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
Computed Descriptors for α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
New Products
2-Amino-5-bromo-4-(trifluoromethyl)pyridine Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
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