(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Synonym(s):(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
- CAS NO.：56715-13-0
- Empirical Formula: C14H22N2O3
- Molecular Weight: 266.34
- MDL number: MFCD00074917
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:56:55
![(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Structural](https://img.chemicalbook.in/CAS/GIF/56715-13-0.gif)
What is (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE?
Description
(+)-Atenolol is an enantiomer of the β1-adrenergic receptor (β1-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.
The Uses of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
The Uses of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Antihypertensor
The Uses of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
less active enantiomer
What are the applications of Application
(R)-(+)-Atenolol is a β-adrenergic blocker
Definition
ChEBI: The (R)-enantiomer of atenolol.
References
[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.
Properties of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
| Melting point: | 148-152 °C(lit.) |
| Boiling point: | 508.0±50.0 °C(Predicted) |
| Density | 1.125±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL |
| form | solid |
| pka | 13.88±0.20(Predicted) |
| color | pale yellow |
| optical activity | [α]25/D +16°, c = 1 in 1 M HCl |
Safety information for (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Computed Descriptors for (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
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