(+/-)11-HETE

Description

(±)11-HETE is an oxylipin formed non-enzymatically from arachidonic acid .^1,2 Levels of (±)11-HETE are increased in an in vitro model of lipid peroxidation induced by ferrous ammonium sulfate (FAS) in rat brain homogenates.³ Levels are also increased in rat liver in an in vivo model of lipid peroxidation induced by carbon tetrachloride (CCl₄). It has been found in skin extracts from individuals with psoriasis and in atherosclerotic plaques.^4,5

What are the applications of Application

(±)11-HETE is one of six monohydroxy fatty acids produced via non-enzymatic oxidation of arachidonic acid

References

1. Powell, W.S., and Rokach, J. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid Biochim. Biophys. Acta 1851(4),340-355(2014).
2. Derogis, P.B.M.C., Chaves-Filho, A.B., and Miyamoto, S. Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometry Bioactive lipids in health and disease ,21-38(2019).
3. Guido, D.M., McKenna, R., and Mathews, W.R. Quantitation of hydroperoxy-eicosatetraenoic acids and hydroxy-eicosatetraenoic acids as indicators of lipid peroxidation using gas chromatography-mass spectrometry Anal. Biochem. 209(1),123-129(1993).
4. Camp, R.D.R., Mallet, A.I., Woollard, P.M., et al. The identification of hydroxy fatty acids in psoriatic skin Prostaglandins 26(3),431-447(1983).
5. Waddington, E., Sienuarine, K., Puddey, I., et al. Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography Anal. Biochem. 292(2),234-244(2001).