CHEMICAL AND PHYSICAL PROPERTIES
| Optical Rotation | Crystals. MW 500.57. MP 272-273 °C (decomposes). Specific optical rotation: +30 deg at 25 °C/D (c = 0.35). Practically insolluble in water. Freely soluble in dimethylsulfoxide, dimethyl formate; slightly soluble in methanol, 95% ethanol. /Fluticasone propionate/ |
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COMPUTED DESCRIPTORS
| Molecular Weight | 444.5 g/mol |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 3 |
| Exact Mass | 444.15821500 g/mol |
| Monoisotopic Mass | 444.15821500 g/mol |
| Topological Polar Surface Area | 99.9 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 861 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 9 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Fluticasone is a trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis. It has a role as an anti-allergic agent and an anti-asthmatic drug. It is an 11beta-hydroxy steroid, a 3-oxo-Delta(4) steroid, a corticosteroid, a fluorinated steroid, a 17alpha-hydroxy steroid and a thioester. It derives from a hydride of an androstane.