COMPUTED DESCRIPTORS
| Molecular Weight | 454.6 g/mol |
|---|---|
| XLogP3 | 7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 12 |
| Exact Mass | 454.22564282 g/mol |
| Monoisotopic Mass | 454.22564282 g/mol |
| Topological Polar Surface Area | 64.4 Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 582 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Octimibate is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with antilipidemic, antiatherosclerotic, and antithrombotic activity. In an animal model, inhibition of ACAT by octimibate increased HDL receptor activity and stimulated HDL-mediated cholesterol efflux from peritoneal macrophages.