CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | LIQUID |
| Boiling Point | 195 °C at 1.20E+01 mm Hg |
| Melting Point | < 25 °C |
| Solubility | Sparingly soluble in water |
| LogP | 3.77 |
| Stability/Shelf Life | SENSITIVE TO LIGHT /CITRATE/ |
| Dissociation Constants | 8.91 |
| Kovats Retention Index | 1950 1924 1924 1924 1915 1925 1943 1932 1950 1927 1948.6 1937.7 1915 1924 1924 1925 1930 1940 1936 1941.2 |
| Other Experimental Properties | SPARINGLY SOL IN WATER, SLIGHTLY SOL IN ETHANOL; INSOL IN CHLOROFORM, DIETHYL ETHER & BENZENE; VERY SLIGHTLY SOL IN ACETONE; MP: 136 DEC C /CITRATE/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 269.4 g/mol |
|---|---|
| XLogP3 | 3.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 6 |
| Exact Mass | 269.177964357 g/mol |
| Monoisotopic Mass | 269.177964357 g/mol |
| Topological Polar Surface Area | 12.5 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 260 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Orphenadrine is a tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol. It has a role as a NMDA receptor antagonist, a H1-receptor antagonist, an antiparkinson drug, a parasympatholytic, a muscle relaxant, a muscarinic antagonist and an antidyskinesia agent. It is a tertiary amino compound and an ether.