81103-11-9
Product Name:
Clarithromycin
Formula:
C38H69NO13
Synonyms:
6-O-methyl erythromycin;CLM
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Colorless needles from chloroform + diisopropyl ether (1:2) ... Also reported as crystals from ethanol |
| Melting Point | 220 dec °C |
| Solubility | 0.33 mg/L |
| LogP | 3.16 |
| Optical Rotation | Specific optical rotation: -90.4 deg at 24 °C/D (c = 1 in CHCl3) |
| Decomposition | When heated to decomposition it emits toxic vapors of /oxides of nitrogen/. |
| Ionization Efficiency | Positive |
| Dissociation Constants | 8.99 |
| Collision Cross Section | 264.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | Stable at acidic pH |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 748.0 g/mol |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 8 |
| Exact Mass | 747.47689126 g/mol |
| Monoisotopic Mass | 747.47689126 g/mol |
| Topological Polar Surface Area | 183 Ų |
| Heavy Atom Count | 52 |
| Formal Charge | 0 |
| Complexity | 1190 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 18 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
Description
Clarithromycin is the 6-O-methyl ether of erythromycin A. clarithromycin is a macrolide antibiotic used to treat respiratory tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in treating peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis. Clarithromycin has a role as an antibacterial drug, a protein synthesis inhibitor, an environmental contaminant and a xenobiotic.