680-31-9
Product Name:
Hexamethylphosphoramide
Formula:
C6H18N3OP
Synonyms:
Hexamethylphosphoric acid triamide;HMPA;Tris(dimethylamino)phosphine oxide
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992) |
|---|---|
| Color/Form | COLORLESS, MOBILE LIQUID |
| Odor | AROMATIC ODOR |
| Boiling Point | 451 °F at 760 mmHg (NTP, 1992) |
| Melting Point | 41 to 45 °F (NTP, 1992) |
| Flash Point | 222 °F (NTP, 1992) |
| Solubility | greater than or equal to 100 mg/mL at 64 °F (NTP, 1992) |
| Density | 1.024 at 77 °F (NTP, 1992) - Denser than water; will sink |
| Vapor Density | 6.18 (NTP, 1992) - Heavier than air; will sink (Relative to Air) |
| Vapor Pressure | 0.07 mmHg at 77 °F (NTP, 1992) |
| Stability/Shelf Life | REACTS UPON HEATING WITH ORG ACIDS TO FORM THE DIMETHYLAMIDE OF THE ORG ACID |
| Decomposition | When heated to decomposition it emits very toxic fume of /phosphine, phosphorus oxides and nitrogen oxides/. |
| Refractive Index | INDEX OF REFRACTION: 1.4572 @ 21 °C/D |
| Other Experimental Properties | DOES NOT HYDROLYZE IN ALKALINE MEDIA BUT HYDROLYZES SLOWLY IN ACIDS |
| Chemical Classes | Other Classes -> Phosphorus Compounds |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Corrosion Corrosives GHS05  Health Hazard GHS08 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H340:Germ cell mutagenicity H350:Carcinogenicity |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 179.20 g/mol |
|---|---|
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 179.11874920 g/mol |
| Monoisotopic Mass | 179.11874920 g/mol |
| Topological Polar Surface Area | 26.8 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 139 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992)