CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Crystals from ethanol |
| Solubility | 9.23e+01 g/L |
| LogP | -6.3 |
| Stability/Shelf Life | Kanamycin sulfate is stable for 24 hours at room temperature in most iv infusion fluids including 0.9% sodium chloride or 5% dextrose injection. |
| Optical Rotation | Crystals, MP 172-192 °C (decomposes). Specific optical rotation: +130 deg at 18 °C/D (c = 0.5 in water); +114 deg at 21 °C/D (c = 0.98 in water). Soluble in water, formamide; slightly soluble in chloroform, isopropyl alcohol. Practically insoluble in the common alcohols and nonpolar solvents. /Kanamycin B/ |
| Decomposition | When heated to decomposition it emits toxic fumes of nitroxides. |
| Dissociation Constants | pKa = 7.2 |
| Collision Cross Section | 206.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix] |
| Other Experimental Properties | White, odorless, crystalline powder. Decompses over a wide range above 250 °C, soluble in water, practically insoluble in methanol and ethanol. /Kanamycin sulfate/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 484.5 g/mol |
|---|---|
| XLogP3 | -6.9 |
| Hydrogen Bond Donor Count | 11 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 6 |
| Exact Mass | 484.23805798 g/mol |
| Monoisotopic Mass | 484.23805798 g/mol |
| Topological Polar Surface Area | 283 Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 638 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 15 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.