CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Melting Point | 200 to 203°C |
| Solubility | Soluble |
| LogP | -0.5 |
| Optical Rotation | Specific optical rotation = +138.5 deg at 20 °C/D (concentration = 0.5 in chloroform) |
| Decomposition | When heated to decomposition, material emits toxic fumes of nitrogen oxides and hydrogen chloride. |
| Dissociation Constants | 7.8 |
| Other Experimental Properties | White to off-white /Midodrine hydrochloride/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 254.28 g/mol |
|---|---|
| XLogP3 | -0.6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 6 |
| Exact Mass | 254.12665706 g/mol |
| Monoisotopic Mass | 254.12665706 g/mol |
| Topological Polar Surface Area | 93.8 Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 263 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Midodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a prodrug, an alpha-adrenergic agonist, a sympathomimetic agent and a vasoconstrictor agent. It is a secondary alcohol, an amino acid amide and an aromatic ether. It is functionally related to a glycinamide and a deglymidodrine. It is a conjugate base of a midodrine(1+).