177036-94-1
Product Name:
Ambrisentan
Formula:
C22H22N2O4
Synonyms:
(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Melting Point | 165-168 °C |
|---|---|
| Solubility | Ambrisentan is practically insoluble in aqueous solutions at low pH. Solubility increases at higher pH. |
| Dissociation Constants | 4.0 |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Health Hazard GHS08 |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. |
COMPUTED DESCRIPTORS
| Molecular Weight | 378.4 g/mol |
|---|---|
| XLogP3 | 3.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 7 |
| Exact Mass | 378.15795719 g/mol |
| Monoisotopic Mass | 378.15795719 g/mol |
| Topological Polar Surface Area | 81.5 Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 475 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Ambrisentan is a diarylmethane.