170809-51-5
Product Name:
ASTRESSIN
Formula:
C161H269N49O42
Synonyms:
[D -Phe12, Nle21,38, Glu30, Lys33]-Corticotropin Releasing Factor fragment 12-41
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COMPUTED DESCRIPTORS
| Molecular Weight | 3563.2 g/mol |
|---|---|
| XLogP3 | -8 |
| Hydrogen Bond Donor Count | 51 |
| Hydrogen Bond Acceptor Count | 49 |
| Rotatable Bond Count | 119 |
| Exact Mass | 3562.0453286 g/mol |
| Monoisotopic Mass | 3561.0419738 g/mol |
| Topological Polar Surface Area | 1490 Ų |
| Heavy Atom Count | 252 |
| Formal Charge | 0 |
| Complexity | 8350 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 32 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Astressin is a 30-membered homodetic cyclic peptide comprising the sequence D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 cyclised by an amide bridge, formed by condensation of the side-chain carboxy group of the Glu residue at position 19 and the side-chain amino group of the Lys residue at position 22. It has a role as a corticotropin-releasing factor receptor antagonist and a neuroprotective agent. It is a homodetic cyclic peptide and a polypeptide.