147403-03-0
Product Name:
Azilsartan
Formula:
C25H20N4O5
Synonyms:
1-[[2′-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl) [1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid;2-Ethoxy-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid;TAK-536
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Colorless prisms from ethanol |
|---|---|
| Melting Point | 212-214 °C |
| LogP | log Kow = 0.90 |
| Stability/Shelf Life | Stable under recommended storage conditions. |
| Decomposition | Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx). |
| Dissociation Constants | pKa at 0.1 N NaOH (26 eg C): 6.1 |
| Other Experimental Properties | Crystals from ethanol /Azilsartan medoxomil/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H361:Reproductive toxicity H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. |
COMPUTED DESCRIPTORS
| Molecular Weight | 456.4 g/mol |
|---|---|
| XLogP3 | 4.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 7 |
| Exact Mass | 456.14336975 g/mol |
| Monoisotopic Mass | 456.14336975 g/mol |
| Topological Polar Surface Area | 115 Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 783 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Azilsartan is an antihypertensive agent that functions as an angiotensin receptor antagonist, playing a significant role in the treatment of hypertension. It is chemically characterized as a benzimidazolecarboxylic acid derivative, with specific substitutions that define its pharmacological properties.