CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Needles or elongated plates from water or ethylene dichloride; [HSDB] |
|---|---|
| Color/Form | Needles or elongated plates from water or ethylene dichloride |
| Taste | Bitter to taste |
| Boiling Point | Sublimes in high vacuum |
| Melting Point | 171 |
| Solubility | 2500 mg/L (at 25 °C) |
| LogP | 1.14 |
| LogS | -2.11 |
| Stability/Shelf Life | Stable under recommended storage conditions. |
| Optical Rotation | Crystals from benzene. MP 90 °C. Practically tasteless. Specific optical rotation: +24.6 deg at 26 °C/D (c= 5 in ethanol), UV max (ethanol): 271 nm (E(1%)(1cm) 179). Very slightly soluble in water (1.05 mg/mL at 28 °C); petroleum ether (0.225 mg/mL). Freely soluble in methanol, ethanol, chloroform, ether, benzene. /Chloramphenicol palmitate/ |
| Decomposition | When heated to decomposition it emits very toxic fumes of /nitrogen oxides and chloride/. |
| pH | Neutral to litmus |
| Caco2 Permeability | -4.69 |
| Collision Cross Section | 163.9 Ų [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Kovats Retention Index | 2310 2310 |
| Other Experimental Properties | Aqueous solutions are neutral. Neutral and acid solutions are stable on heating. |
| Chemical Classes | Other Uses -> Pharmaceuticals |
COMPUTED DESCRIPTORS
| Molecular Weight | 323.13 g/mol |
|---|---|
| XLogP3 | 1.1 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 5 |
| Exact Mass | 322.0123269 g/mol |
| Monoisotopic Mass | 322.0123269 g/mol |
| Topological Polar Surface Area | 115 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 342 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Chloramphenicol is an organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions. It has a role as an antimicrobial agent, an antibacterial drug, a protein synthesis inhibitor, an Escherichia coli metabolite, a Mycoplasma genitalium metabolite and a geroprotector. It is an organochlorine compound, a diol, a C-nitro compound and a carboxamide.