119-04-0
Product Name:
NEOMYCIN B
Formula:
C23H46N6O13
Synonyms:
(2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]-D-streptamine sulfate);Antibiotic 10676;Neomycin B
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Liquid |
|---|---|
| Melting Point | 6 °C (sulfate form) |
| Solubility | Soluble in water ... solutions up to 250 mg/mL may be prepared |
| LogP | -7.8 |
| Henry's Law Constant | Henry's Law constant range: 8.5X10-12 to 4.1X10-8 Pa-cu m/mol (Aminoglycosides) (etc) |
| Stability/Shelf Life | Hygroscopic. /Neomycin sulfate/ |
| Optical Rotation | Crystals from methanol, MP 334-336 °C. Specific optical rotation at 25 °C for D (sodium) line = +87 deg (c = 1) /Neomycin A N-acetyl derivative/ |
| Decomposition | When heated to decomposition it emits acrid smoke and irritating fumes. |
| Refractive Index | INDEX OF REFRACTION: 1.541 (ALPHA), ISOTROPIC /NEOMICIN SULFATE/ |
| Dissociation Constants | pKa = 12.9; pKb = 9.52 (25 °C) |
| Collision Cross Section | 238.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix] |
| Other Experimental Properties | Mol wt 322.36. Crystals from water or aqueous alcohol, decomposes at 225-226 °C, specific optical rotation at 25 °C for D (sodium) line = +112.8 deg (c = 1) /Neomycin A/ |
| Chemical Classes | Other Uses -> Pharmaceuticals |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
COMPUTED DESCRIPTORS
| Molecular Weight | 614.6 g/mol |
|---|---|
| XLogP3 | -9 |
| Hydrogen Bond Donor Count | 13 |
| Hydrogen Bond Acceptor Count | 19 |
| Rotatable Bond Count | 9 |
| Exact Mass | 614.31228554 g/mol |
| Monoisotopic Mass | 614.31228554 g/mol |
| Topological Polar Surface Area | 353 Ų |
| Heavy Atom Count | 42 |
| Formal Charge | 0 |
| Complexity | 872 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 19 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Framycetin is a tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B. It has a role as an antibacterial drug, an allergen and an Escherichia coli metabolite. It is a conjugate base of a framycetin(6+).